Data mining for feature selection in gene expression autism data

We have developed the system of gene selection from microarray data in autism composed of an ensemble of methods.We have developed the system of recognizing the autism applying the classifiers cooperating with gene selection.We have performed successful experiments of recognizing autism from reference cases using our system. The paper presents application of data mining methods for recognizing the most significant genes and gene sequences (treated as features) stored in a dataset of gene expression microarray. The investigations are performed for autism data. Few chosen methods of feature selection have been applied and their results integrated in the final outcome. In this way we find the contents of small set of the most important genes associated with autism. They have been applied in the classification procedure aimed on recognition of autism from reference group members. The results of numerical experiments concerning selection of the most important genes and classification of the cases on the basis of the selected genes will be discussed. The main contribution of the paper is in developing the fusion system of the results of many selection approaches into the final set, most closely associated with autism. We have also proposed special procedure of estimating the number of highest rank genes used in classification procedure.