the bioactivity of hexadecanoic acid compound isolated from hydroid aglaophenia cupressina lamoureoux as antibacterial agent against salmonella typhi
2016
Background & Objectives: The new, more effective antibiotic sources are urgently needed now
to overcome the multi-drug resistance (MDR) in the treatment of infectious diseases caused by
pathogenic microorganisms. This study was aimed to find out the bioactivity of the
hexadecanoic acid isolated from hydroid AglaopheniacupressinaLamoureoux with inhibition
mechanisms or lethal to Salmonella typhi that frequently contaminate food materials.
Methods: This study was an experimental study with the following treatment steps: Isolation
and characterization of the compounds from hydroid A. cupressinaLamoureoux by
chromatography. Hexadecanoic acids and the isolates from hydroid A. cupressinaLamoureoux
were then tested against S. typhi at various concentrations (10 ppm, 20 ppm, and 30 ppm).
Result: Study findings indicated that: (1) hexadecanoic acid at the concentration of 30 ppm is
bactericidal against S. syphi.Interpretation & Conclusion: From the study findings, it can be
concluded that hexadecanoic acid (30 ppm) has antibacterial activity by damaging the cells
wall of S. typhi.
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