Evidence that processing of ribonucleotides in DNA by topoisomerase 1 is leading-strand specific

Jessica S. Williams,Anders Ranegaard Clausen,Scott A. Lujan,Lisette Marjavaara,Alan B. Clark,Peter M. J. Burgers,Andrei Chabes,Thomas A. Kunkel

Evidence that processing of ribonucleotides in DNA by topoisomerase 1 is leading-strand specific

2015

Jessica S. Williams
Anders Ranegaard Clausen
Scott A. Lujan
Lisette Marjavaara
Alan B. Clark
Peter M. J. Burgers
Andrei Chabes
Thomas A. Kunkel

Ribonucleotides incorporated during DNA replication are removed by RNase H2-dependent ribonucleotide excision repair (RER). In RER-defective yeast, topoisomerase 1 (Top1) incises DNA at unrepaired ...

Keywords:

DNA replication
Topoisomerase
Replisome
Prokaryotic DNA replication
DNA polymerase
Molecular biology
Ribonucleotide excision repair
DNA supercoil
Replication protein A
Biochemistry
Biology

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