Serine derived NK1 antagonists. 1: The effect of modifications to the serine substituents.

Jason Matthew Elliott,Margaret A. Cascieri,Gary G. Chicchi,S. Davies,Fintan Kelleher,Marc M. Kurtz,T. Ladduwahetty,Richard Thomas Lewis,Angus Murray Macleod,Kevin John Merchant,Sharon Sadowski,Graeme Irvine Stevenson

Serine derived NK1 antagonists. 1: The effect of modifications to the serine substituents.

1998

Jason Matthew Elliott
Margaret A. Cascieri
Gary G. Chicchi
S. Davies
Fintan Kelleher
Marc M. Kurtz
T. Ladduwahetty
Richard Thomas Lewis
Angus Murray Macleod
Kevin John Merchant
Sharon Sadowski
Graeme Irvine Stevenson

Abstract A series of novel serine derived NK 1 antagonists is described. The effect of variations in the N -benzyl, O -benzyl and serine groups are use to define the elements which are necessary for binding.

Keywords:

Chemical synthesis
Organic chemistry
Serine
Biochemistry
Stereochemistry
Carboxamide
Chemistry
chain length
Stereoisomerism
In vitro
Antagonist
Structure–activity relationship

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