Exploring clustering of leprosy in the Comoros and Madagascar: a geospatial analysis.

Abstract Objectives To identify patterns of spatial clustering of leprosy. Design We performed a baseline survey for a trial on post-exposure prophylaxis for leprosy in Comoros and Madagascar. We screened 64 villages, door-to-door, and recorded results of screening, demographic data and geographic coordinates. To identify clusters, we fitted a purely spatial Poisson model using Kulldorff’s spatial scan statistic. To assess at the individual level the risk of suffering from leprosy as a function of distance to the nearest known leprosy patient, we used a regular Poisson model. Results We identified 455 leprosy patients, 200 (44.0%) belonging to 2,735 households included in a cluster. Thirty-eight percent of leprosy patients versus ten percent of the population live within 25 meters of another leprosy patient. The risk ratios for being diagnosed with leprosy were 7.3 (5.1-10.4), 2.4 (1.7-3.4), 1.8 (1.3-2.5), 1.4 (1.0-2.1) and 1.7 (1.1-2.4) respectively for those living in the same household, at 1- Conclusions We documented significant clustering of leprosy beyond the household-level, though 56% of cases were not part of a cluster. Control measures need to be extended beyond the household and social networks should be further explored.