Design, Synthesis, Activity, and Structure of a Novel Class of Matrix Metalloproteinase Inhibitors Containing a Heterocyclic P2′-P3′ Amide Bond Isostere.
2010
Abstract A novel series of hydrozamate-based inhibitors of matrix metalloproteinases containing benzimidazole and imidazole heterocyles as amide bond isosteres have been prepared. Potent inhibition (in the low nanomolar range) and selectivity (> 100-fold) can be attained with inhibitors containing only one amide bond. X-ray crystal structures of matrilysin (MMP-7) with two different inhibitors bound confirm that imidazole is an excellent amide bond isostere.
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