Mapping attenuation coefficient characteristics of cataracts with optical coherence tomography

Optical coherence tomography (OCT) is an interferometric imaging technique that provides non-destructive volumetric visualization of tissues. OCT has been previously proposed as a method to analyze lens cataracts in humans and animal models. In our previous work we showcased the use of a custom-made OCT system to image the crystalline lenses of mice in vivo based on scattering contrast. We now extend our previous results and propose the attenuation coefficient as a parameter for quantitative mapping the lenticular opacities, revealing a significant difference between eyes with ocular cataracts and normal eyes.