Distribution and antibiotic resistance of pathogens in lower respiratory tract infection in children

Objective To investigate the distribution of infection pathogens and their antibiotic resistance in lower respiratory tract infection in children and provide basis for reasonable use of drugs in clinical practice. Methods The culturing results and drug resistance of 384 strains of bacteria isolated from 1350 specimen of lower respiratory tract infection in children from May 2009 to May 2012 in our hospital were analyzed retrospectively. Results 384 strains of bacteria were isolated and the detection rate was 28. 4%,including 258strains( 67. 2%) of Gram negative bacilli( G-),95 strains( 24. 7%) of Gram-positive cocci( G+),17 strains( 4. 4%) of anaerobic bacteria and 14 strains( 3. 6%) of fungi. Klebsiella pneumoniae,Escherichia coli and Klebsiella ornithinolytica were the top three G-bacilli and their resistances to ampicillin and piperacillin were above 50%. There were 57 extended spectrum β-lactamase-producing strains and the positive rate was 43. 2%. The first three G+cocci were Streptococcus pneumoniae,Staphylococcus aureus and Staphylococcus aureus,and their resistances to penicillin and erythromycin were above 50% too. Conclusion The main pathogens in lower respiratory tract infection in children in our hospital are Gram-negative bacilli. It is important to strengthen the monitoring of bacteria and drug resistance for clinical rational use of antibiotics.