High-Pressure Crystallography of Biomolecules: Recent Achievements. II – Applications

This chapter gives various applications around the general theme of macromolecular crystallography (MX) and high pressure (HP). We first describe high-pressure cooling where crystallographic data collection is performed at ambient pressure. Then we give selected examples with data collection at high pressure (HPMX); they include compressibility measurements and structural studies on polynucleotides, an oligomeric protein and a virus capsid. Finally, we show that high pressure and methods developed for HPMX have impacts on conventional MX.