T cells dampen innate immune responses through inhibition of NLRP1 and NLRP3 inflammasomes

The mechanisms controlling excessive inflammatory responses, which can result in damage to tissues and diseases such as arthritis and type-2 diabetes, are poorly understood. Mouse effector and memory CD4+ T cells are now shown to inhibit inflammasome activity, revealing a mechanism by which effector and memory T cells can suppress potentially damaging inflammation while leaving the primary inflammatory response intact.