Research progress in Filifactor alocis interacting with periodontitis

Many new microbial species which are correlated with periodontitis have been identified in addition to the"red complex"cultured by conventional methods due to the development of high-throughput sequencing technology. Filifactor alocis (Fa), as a anaerobic Gram-positive bacteria, is closely related to the occurrence and development of periodontitis. Fa can not only destroy host cells and induce immune escape response, but also interact with other periodontal pathogens to promote the periodontitis. This article summarizes and discusses the research progress on the relationship between Fa and periodontitis in recent years and highlighs a new way to investigate the etiology, prevention and treatment of periodontitis.