Botanochimie : utilisation de matériel végétal comme alternative originale pour la résolution cinétique du 1-phényléthyl acétate

High valuable enantiomerically pure compounds are potential chiral building blocks for the synthesis of pharmaceutically important molecules, agrochemicals, flavours and asymmetric chiral ligands. A novel methodology coined “botanochemistry” investigates the possibility of using directly freshly cut pieces of various vegetables, without any other processing to perform important chemical transformations. The present work aims to optimize the time required for the preparation of the biocatalysts and to screen among fruit and vegetable organs for this purpose. It was observed that most of those biocatalysts contain specific enzymes that hydrolyse exogenous organic substrates. The red beetroot skin has been selected as the most promising biocatalyst to perform the kinetic resolution of (±)-1-phenylethyl acetate with excellent enantiomeric excess. The main advantage of this approach, as compared to the chemical procedures, (metal- and organo-catalysis), is that the final consequences of these transformations are more ecologically friendly, economically promising and also enables the valorization of by-products issued from agriculture and food industries.