Downregulation of Long Non-Coding RNA Kcnq1ot1: An Important Mechanism of Arsenic Trioxide-Induced Long QT Syndrome

Yanan Jiang,Weijie Du,Qun Chu,Ying Qin,Gulnara Tuguzbaeva,Hui Wang,Anqi Li,Guiyang Li,Yanyao Li,Lu Chai,Er Yue,Xi Sun,Zhiguo Wang,Valentin Pavlov,Baofeng Yang,Yunlong Bai

Downregulation of Long Non-Coding RNA Kcnq1ot1: An Important Mechanism of Arsenic Trioxide-Induced Long QT Syndrome

2018

Yanan Jiang
Weijie Du
Qun Chu
Ying Qin
Gulnara Tuguzbaeva
Hui Wang
Anqi Li
Guiyang Li
Yanyao Li
Lu Chai
Er Yue
Xi Sun
Zhiguo Wang
Valentin Pavlov
Baofeng Yang
Yunlong Bai

Background/Aims: Arsenic trioxide (ATO) is a known anti-acute promyelocytic leukemia (APL) reagent, whose clinical applications are limited by its serious cardiac

Keywords:

Arsenic trioxide
KCNQ1OT1
Cancer research
Long QT syndrome
Long non-coding RNA
Downregulation and upregulation
Leukemia
Biology
Biochemistry
In vivo
QT interval
Gene knockdown
Gene silencing

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