Hiperparatiroidismo secundario inducido por plaquetoféresis como resultado de la quelación de los cationes divalentes por el citrato

Background: Apheresis allows to collect specific and high-quality blood components but changes serum calcium and magnesium concentrations due to citrate infusion. Aim: To compare pre and post-plateletpheresis serum levels of calcium (Ca), magnesium (Mg), zinc (Zn), copper (Cu) and parathyroid hormone (PTH) among donors. Materials and methods: Prospective study including 105 donors. Basal and post-procedure serum levels of PTH, Ca, Mg, Zn and Cu were measured by ion selective potentiometry, final dot, atomic absorption and solid phase two site chemoluminiscence. In case of adverse reactions a blood sample was drawn to analyze concentrations of such hormone and minerals. We intended to correlate both, diet and adverse reactions with levels of aforementioned elements. Statistical analysis included X2 and ANOVA. Protocol was approved by the ethical and research committee. Results: One hundred five