Modulation of Redox Homeostasis by Inhibition of MTHFD2 in Colorectal Cancer: Mechanisms and Therapeutic Implications

Huaiqiang Ju,Yun Xin Lu,Dong Liang Chen,Zhi Xiang Zuo,Zexian Liu,Qinian Wu,Hai Yu Mo,Zi Xian Wang,De-shen Wang,Heng Ying Pu,Zhaolei Zeng,Bo Li,Dan Xie,Peng Huang,Mien Chie Hung,Paul J. Chiao,Rui Hua Xu

Modulation of Redox Homeostasis by Inhibition of MTHFD2 in Colorectal Cancer: Mechanisms and Therapeutic Implications

2018

Huaiqiang Ju
Yun Xin Lu
Dong Liang Chen
Zhi Xiang Zuo
Zexian Liu
Qinian Wu
Hai Yu Mo
Zi Xian Wang
De-shen Wang
Heng Ying Pu
Zhaolei Zeng
Bo Li
Dan Xie
Peng Huang
Mien Chie Hung
Paul J. Chiao
Rui Hua Xu

Background Overcoming oxidative stress is a critical step for tumor progression; however, the underlying mechanisms in colorectal cancer (CRC) remain unclear.

Keywords:

Redox
Immunology
Cancer research
Homeostasis
Colorectal cancer
Biology
Tumor progression
Carcinogenesis
In vivo
Oxidative stress
Cell growth
Metastasis
Programmed cell death

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