Evaluation of short chain chlorinated paraffins in human milk and their intake by infants in Hebei Province, China

ABSTRACTShort-chain chlorinated paraffins (SCCPs) have drawn increasing interest worldwide since they were included in the list of controlled persistent organic pollutants in Annex A of the Stockholm Convention in 2017, and the potential health risk they pose to humans must be evaluated. In this study, 86 human milk samples were collected from 55 healthy Chinese mothers living in the Shijiazhuang region of Northern China in 2014–2015. Advanced online gel permeation chromatography–gas-chromatography-coupled mass spectrometry with negative-ion chemical ionisation was used to quantify the SCCPs in the samples. The estimated mean level of SCCPs was 2.51 μg g−1 lipid weight (range 0.21–16.12). The SCCP concentration correlated positively with the mother’s bodyweight at the end of pregnancy (P < 0.05). The mean SCCP intake by infants via breast milk was 13.0 μg kg−1 day−1 at 1 month, 7.1 μg kg−1 day−1 at 3 months, and 2.5 μg kg−1 day−1 at 6 months after birth. This study provides initial data on the levels of S...