Preclinical and clinical in vitro in vivo correlation of an hGH dextran microsphere formulation.

K.D.F. Vlugt-Wensink,R. de Vrueh,M. G. Gresnigt,C. M. Hoogerbrugge,S.C. van Buul-Offers,L.G. de Leede,L. G. W. Sterkman,Daan J.A. Crommelin,Wim E. Hennink,Ruud Verrijk

Preclinical and clinical in vitro in vivo correlation of an hGH dextran microsphere formulation.

2007

K.D.F. Vlugt-Wensink
R. de Vrueh
M. G. Gresnigt
C. M. Hoogerbrugge
S.C. van Buul-Offers
L.G. de Leede
L. G. W. Sterkman
Daan J.A. Crommelin
Wim E. Hennink
Ruud Verrijk

Purpose To investigate the in vitro in vivo correlation of a sustained release formulation for human growth hormone (hGH) based on hydroxyethyl methacrylated dextran (dex-HEMA) microspheres in Pit-1 deficient Snell dwarf mice and in healthy human volunteers.

Keywords:

Insulin-like growth factor-binding protein
Microparticle
Drug delivery
Blood substitute
In vivo
Dextran
Pharmacology
Drug carrier
In vitro
Chemistry
in vitro in vivo
Microsphere
human growth hormone

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