Determination of trace cobalt and tungsten in human urine by inductively coupled plasma mass spectrometry

Objective To establish a method to determine cobalt and tungsten in human urine by ICP-MS. Methods Both Co and W were linear within 0.05~10.00 ng/ml with r>0.999. Spike experiment showed that both Co and W received good recovery rate, which were 90%~97%. Intra-assay precisions were 3.2%~5.1% for Co and 2.2%~4.1% for W, inter-assay precisions were 4.4%~5.2% for Co and 3.7%~4.5% for W. Results Conclusion The method by using ICP-MS to determine urine Co and W was fast, accurate and with low matrix effect. It could meet the requirement in GBZ/T 210.5-2008. Key words: Cobalt; Tungsten; Spectrometry, mass, secondory ion