The immunosuppressive characteristics of FB1 by inhibition of maturation and function of BMDCs

Abstract Fumonisin B 1 (FB 1 ) is one kind of mycotoxins that has the neurotoxicity, carcinogenicity, hepatotoxicity and immunotoxicity produced by the fungus Fusarium verticillioides , which commonly infects corn and other crops and is harmful to animal and human health upon consumption of FB 1 -contaminated feed or food. However, the mechanism of immunotoxicity, especially the immunosuppression induced by FB 1 is still unclear. The most pivotal cells in the induction of immune responses are dendritic cells (DCs). In this study, we used murine bone marrow-derived dendritic cells (BMDCs) as a model system to elucidate the effect of FB 1 on the function of BMDCs through biological methods. We found that FB 1 reversed the morphological changes and enhanced the endocytosis of FITC-dextran in LPS-treated BMDCs. At the same time, FB 1 decreased the LPS-induced expressions of MHC II, C[1]D80 and CD86 molecules in BMDCs ( p p 1 in a dose dependent ( p 1 were mainly caused by changing the morphology and interfering with the process of antigen uptake, processing and presentation. The results highlighted that FB 1 had the capacity to modulate the immune responses of BMDCs.