The activity of leukocyte NADPH oxidase: regulation by p47PHOX cysteine and serine residues.

The leukocyte NADPH oxidase is regulated chiefly by phosphorylation of the serines of p47PHOX, one of its cytosolic subunits. Its activity is also regulated, however, by the four cysteines of the same subunit, as indicated by the replacement of those cysteines by alanines.