Straightening up is required to nucleate new microtubules.
2021
In this issue, Ayukawa, Iwata, Imai, and colleagues (2021. J. Cell Biol.https://doi.org/10.1083/jcb.202007033) use rapid temporal and high-spatial-resolution electron microscopy imaging to examine the earliest stages of new microtubule nucleation. They discover that straightening of curved tubulin oligomers increases the efficiency of microtubule nucleation.
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