A convenient preparation method of aspoxicillin sodium

The present invention discloses a convenient method for the preparation of sodium amoxicillin apomorphine, D- aspartic acid was added to the mixture, thionyl chloride and methanol D- aspartic acid methyl ester hydrochloride prepared by reacting at low temperatures salt, the reaction with aqueous methylamine asparagine carboxamide available, the primary amino group on the asparagine carboxamide protected with a trifluoroacetyl group, followed by forming a mixed acid anhydride with an active carbonyl diimidazole, then amoxicillin and triethylamine salt condensation, and finally de-protecting groups under basic conditions and a sodium salt, to give the desired product aspoxicillin crude final high purity can be purified aspoxicillin sodium finished. The present invention is inexpensive, readily available reagents having, toxicity and environmental advantages of high purity pressure is small, simple and stable process operation.