Study on relation of laminin receptor and different bile duct carcinoma metastatic cell strains

To investigate the expression of laminin receptor in different bile duct carcinoma cell strains, a peritoneum infiltration screening model was established to screen out the different metastatic cell strains of bile duct carcinoma. Invasive experiments in vitro were adopted to validate the results. The difference of LNR expression was compared both in the high and low cell strains by flow cytometry analysis. The results showed that by using the peritoneum infiltration screening model,high and low metastatic QBC939 cell strains were successfully screened out. Invasive experiments in vitro also proved that the invasive ability of high cell strain was stronger than that of the low one. The positive rate of LNR in high strains (36.36 ± 9.22)% was higher than that in the low ones (13.17 ± 3.43)%, and the difference was significant (P < 0.05). It can be concluded that laminin receptor may be related with the metastatic process of bile duct carcinoma.