The neuronal transporter gene SLC6A15 confers risk to major depression

Martin A. Kohli,1,16,* Susanne Lucae,1,16 Philipp G. Saemann,1 Mathias V. Schmidt,1 Ayse Demirkan,2 Karin Hek,2 Darina Czamara,1 Michael Alexander,3 Daria Salyakina,1 Stephan Ripke,1 David Hoehn,1 Michael Specht,1 Andreas Menke,1 Johannes Hennings,1 Angela Heck,1 Christiane Wolf,1 Marcus Ising,1 Stefan Schreiber,4 Michael Czisch,1 Marianne B. Muller,1 Manfred Uhr,1 Thomas Bettecken,1 Albert Becker,5 Johannes Schramm,6 Marcella Rietschel,7 Wolfgang Maier,8 Bekh Bradley,9,10 Kerry J. Ressler,9,11,12 Markus M. Nothen,13 Sven Cichon,3,14 Ian W. Craig,15 Gerome Breen,15 Cathryn M. Lewis,15 Albert Hofman,2 Henning Tiemeier,2 Cornelia M. van Duijn,2 Florian Holsboer,1 Bertram Muller-Myhsok,1,17 and Elisabeth B. Binder1,9,17,* 1Max Planck Institute of Psychiatry, D-80804 Munich, Germany 2Erasmus University Medical Center, Department of Epidemiology, 300 CA Rotterdam, The Netherlands 3Institute of Human Genetics, Department of Genomics, Life & Brain Center, University of Bonn, D-53127 Bonn, Germany 4Christian-Albrechts University, Department of General Internal Medicine, D-24105 Kiel, Germany 5Institute for Neuropathology, University Clinics Bonn, D-53127 Bonn, Germany 6Department of Neurosurgery, University Clinics Bonn, D-53127 Bonn, Germany 7Department of Genetic Epidemiology in Psychiatry, Central Institute of Mental Health, University of Heidelberg, D-68159 Mannheim, Germany 8Department of Psychiatry, University of Bonn, D-53105 Bonn, Germany 9Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, GA 30322, USA 10Howard Hughes Medical Institute, Chevy Chase, MD 20815, USA 11Yerkes National Primate Research Center, Atlanta, GA 30329, USA 12Atlanta VA Medical Center, Atlanta, GA 30033, USA 13Institute of Human Genetics, University of Bonn, D-53115 Bonn, Germany 14Institute of Neurosciences and Medicine (INM-1), Research Center Juelich, D-52425 Juelich, Germany 15Institute of Psychiatry, King’s College London, SE5 8AF London, UK 16These authors contributed equally to this work 17These authors contributed equally to this work *Correspondence: mkohli@med.miami.edu (M.A.K.), binder@mpipsykl.mpg.de (E.B.B.) DOI 10.1016/j.neuron.2011.04.005