Design optimization of a small-animal SPECT system using LGSO continuous crystals and micro parallel-hole collimators

A small-animal single photon emission computed tomography (SPECT) system having compact size and low cost was designed using monolithic LGSO scintillation crystals and micro parallel-hole collimators through Monte Carlo simulations. A spatial resolution of ~1 mm and a sensitivity of ~100 cps/MBq were achieved with a four-head SPECT system. A hot rod with a diameter of 1.0 mm was resolved in the SPECT image of the ultra-micro hot spot phantom. Using a thin monolithic crystal and micro collimator, we achieved high spatial resolution and high sensitivity.