Changes in the lipoprotein profile during antihypertensive therapy

: In the Oslo study serum lipids have been studied during treatment with some of the most frequently used antihypertensive drugs. Hydrochlorothiazide induced no significant changes. However, those patients with the most marked increase in uric acid showed an increase of serum ti iglycerides. Total cholesterol was unchanged in these men. The β-adrenoceptorblocking drugs propranolol, aterolol and oxprenolol caused a reduction of HDL cholesterol and an increase of total triglycerides. Tolal cholesterol remained unchanged. Pindolol induced no significant lipoprotein changes. Prazosin reduced total cholesterol and total triglycerides. HDL. cholesterol remained unchanged. LDL + VLDL cholesterol was reduced.