Origin of intracellular Ca2+ concentration increase by hypoxia differs between Muller cells and ganglion cells

It is thought that ischemia-induced neuronal cell death is triggered by calcium influx through the glutamate receptor. However, the intracellular Ca2+ concentration ([Ca2+]i) change by ischemic damage has not been studied in individual cell types. We measured [Ca2+]i change, caused by a hypoxic condition, of Muller cells (MC) and ganglion cells (GC) by selective loading of Ca-sensitive dyes in sliced rat retina.