Improved Catalytic Procedures for the Copper(I)-Promoted Reactions of β-Amido Zinc Reagents.

Copper-catalysed cross coupling of the β-aminoalkylzinc reagents 1a and 2 with unsaturated alkyl halides gives β-unsaturated ethylamines in 47–78% yield (4 examples) and enantiomerically pure β-unsaturated propylamines in 55–69% yield (3 examples). This method is more efficient for simple β-aminoalkylzinc reagents than that using stoichiometric copper.