Two new ent-kauranoids from Isodon sculponeata

Two new ent-kaurane diterpenoids, sculponcatins L (1) and M (2), were isolated from the EtOAc extract of Isodon sculponeata. Their structures were elucidated by spectroscopic evidences. The cytotoxicities of 1 and 2 against human tumor cells K562 andT24 were tested.