Environmental Toxicology MODELING PCB TRANSFER INTO HEN EGGS: INFLUENCE OF PHYSIOLOGICAL CHARACTERISTICS OF THE ANIMAL

yUniversite de Lorraine, ENSAIA, UR Animal et Fonctionnalites des Produits Animaux, Vandoeuvre-les-Nancy, FrancezINRA, USC 340 Animal et Fonctionnalites des Produits Animaux, Vandoeuvre-les-Nancy, FrancexAgroParisTech, UMR Modelisation Systemique Appliquee aux Ruminants, Paris, FrancekINRA, UMR 791, Modelisation Systemique Appliquee aux Ruminants, Paris, France#ITAVI, UMT Bird, INRA, UR83 Recherches Avicoles, Nouzilly, France(Submitted 2 August 2014; Returned for Revision 15 September 2014; Accepted 10 October 2014)Abstract: Laying hens are likely to be exposed to a wide range of persistent organic pollutants (POPs), including polychlorinatedbiphenyls(PCBs).ToimprovethesafetyofpoultryfarmingsystemsintermsofPOPs,thepresentresearchfocusedonassessingtheimpactof physiological characteristics of the hen on the transfer of ingested PCBs to eggs. Modeling was used as a research tool to explore theimpactofsomephysiologicalcharacteristicsonthetransferofPCBsinthelayinghen.Themathematicalmodelsimulatesthedynamicsofthe size of the lipid compartments in the animal and the frequency of laying, with the PCB concentrations in egg yolk and adipose tissuebeing model outputs. Simulations were run to assess effects of animal characteristics on the transfer of PCBs to eggs. Laying rateproportionallyinfluencedthePCBlevelofeggsandadiposetissueatsteadystate.BodyfatdilutedabsorbedPCBsintheabsenceoflayingand significantly influenced the decontamination rate of tissues during depuration after an exposure period. Application of the presentmodel to actual exposure cases highlights its value in improving the support of risk management in livestock farming. Environ ToxicolChem 2014;9999:1–11. # 2014 SETACKeywords: Poultry Model Persistent organic pollutants Kinetics MoltINTRODUCTION