Modulating the Pro-apoptotic Activity of Cytochrome c at a Biomimetic Electrified Interface
2021
Programmed cell death via
apoptosis is a natural defence against excessive cell division, crucial at all
stages of life from foetal development to maintenance of homeostasis and
elimination of precancerous and senescent cells. Here we demonstrate an
electrified liquid bio-interface that replicates the molecular machinery of the
inner mitochondrial membrane at the onset of apoptosis. By mimicking in vivo
cytochrome c (Cyt c)
interactions with cell membranes, our platform allows us to modulate the conformational plasticity
of the protein by simply varying the electrochemical environment at an
aqueous|organic interface. As proof-of-concept, we use our electrified liquid
bio-interface to identify drug molecules that can potentially downregulate Cyt c and protect against uncontrolled
neuronal cell death in Alzheimer’s disease and other neurodegenerative
disorders.
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