Oxazepines as modulators of ion channels

A compound of Formula I: ** ** formulas wherein: -YZ- is -C (> = NR4) -NR2 - or -C (NR5R6)> = N-; R1 is aryl, cycloalkyl, cycloalkenyl, heterocyclyl or heteroaryl; wherein said aryl, cycloalkyl, cycloalkenyl, heterocyclyl or heteroaryl are optionally substituted with one, two or three substituents independently selected from the group consisting of halo, -NO2, -CN, -SF 5, -Si (CH3) 3, -O -R20, -S-R20, -C (O) -R20, -C (O) -OR20, -N (R20) (R22), -C (O) -N (R20) (R22), -N ( R20) -C (O) -R22, -N (R20) - C (O) -OR22, -N (R20) -S (> = O) 2-R26, -S (> = O) 2-R20, -OS (O) 2-R20, -S (> = O) 2 N (R20) (R22), C1-6 alkyl, C2-4 alkenyl, C2-4 alkynyl, cycloalkyl, aryl, heteroaryl and heterocyclyl; and wherein said C1-6 alkyl, C2-4 alkenyl, C2-4 alkynyl, cycloalkyl, aryl, heteroaryl or heterocyclyl are optionally substituted with one, two or three substituents independently selected from the group consisting of halo, -NO 2, phenyl , heterocyclyl, heteroaryl, C1-6 alkyl, cycloalkyl, -N (R20) (R22), -C (O) -R20, - C (O) -OR20, -C (O) -N (R20) (R22) , -CN and -O-R20; R2 is hydrogen, alkyl, -C (O) -R20, -C (O) -OR 26, -C (O) -N (R26) (R26), -N (R20) -S (> = O) 2- R20, cycloalkyl, aryl, heteroaryl or heterocyclyl; wherein said C1-6 alkyl, cycloalkyl, aryl, heteroaryl or heterocyclyl are optionally substituted with one, two or three substituents independently selected from the group consisting of C1-6 alkyl, C2-4 alkynyl, halo, -NO2, cycloalkyl, aryl, heterocyclyl, heteroaryl, -N (R20) (R22), -C (O) -R20, -C (O) -OR20, -C (O) - N (R20) (R22), -CN, oxo and -O-R20; wherein said C1-6 alkyl, cycloalkyl, aryl, heterocyclyl or heteroaryl are further optionally substituted with one, two or three substituents independently selected from the group consisting of halo, -NO2, C1-6 alkyl, cycloalkyl, aryl, heterocyclyl, heteroaryl, -N (R20) (R22), -C (O) -R20, -C (O) -OR20, -C (O) - N (R20) (R22), -CN and -O-R20; and wherein said C1-6 alkyl, cycloalkyl, aryl, heterocyclyl or heteroaryl are further optionally substituted with one, two or three substituents independently selected from the group consisting of halo, -NO2, -CF3, -N (R20) (R22 ), -C (O) -R20, -C (O) -OR20, -C (O) -N (R20) (R22), -CN, -S (O) 2 R20, and -O-R20; n is 0, 1, 2, 3 or 4; each R3 is independently C1-6 alkyl, cycloalkyl, aryl, heteroaryl or heterocyclyl; wherein said C1-6 alkyl is optionally substituted with one, two or three substituents independently selected from the group consisting of halo, -NO2, cycloalkyl, aryl, heterocyclyl, heteroaryl, -N (R20) (R22), -C ( O) -R20, -C (O) -OR20, -C (O) -N (R20) (R22), -CN and -O-R20; wherein said cycloalkyl, aryl, heterocyclyl or heteroaryl are further optionally substituted with one, two or three substituents independently selected from the group consisting of halo, -NO2, C1-6 alkyl, aralkyl, cycloalkyl, aryl, heterocyclyl, heteroaryl alkyl, - N (R20) (R22), -C (O) -R20, -C (O) -OR20, -C (O) - N (R20) (R22), -CN and -O-R20; and wherein said C1-6 alkyl, aralkyl, cycloalkyl, aryl, heterocyclyl or heteroaryl are further optionally substituted with one, two or three substituents independently selected from the group consisting of halo, -NO 2, -N (R20) (R22 ), -C (O) -R20, -C (O) -OR20, -C (O) -N (R20) (R22), -CN and -O-R20, or two R3 joined to a common carbon atom They form an oxo; or two R3 joined to adjacent atoms common carbon or form a cycloalkyl or heterocyclyl; wherein said cycloalkyl or heterocyclyl are further optionally substituted with one, two or three substituents independently selected from the group consisting of halo, -NO2, C1-6 alkyl, aralkyl, cycloalkyl, aryl, heterocyclyl, heteroaryl, -N (R20) (R22), -C (O) -R20, -C (O) -OR20, -C (O) -N (R20) (R22), -CN and -O-R20; R4 is C1-6 alkyl, cycloalkyl, aryl, heteroaryl or heterocyclyl; wherein said C1-6 alkyl, cycloalkyl, aryl, heteroaryl or heterocyclyl are optionally substituted with one, two or three substituents independently selected from the group consisting of halo, -NO2, cycloalkyl, aryl, heterocyclyl, heteroaryl, -N (R20 ) (R22), -C (O) -R20, -C (O) -OR20, -C (O) -N (R20) (R22), -CN and -O-R20; wherein said cycloalkyl, aryl, heterocyclyl or heteroaryl are further optionally substituted with one, two or three substituents independently selected from the group consisting of halo, -NO2, C1-6 alkyl, aralkyl, cycloalkyl, aryl, heterocyclyl, heteroaryl alkyl, - N (R20) (R22), -C (O) -R20, -C (O) -OR20, -C (O) - N (R20) (R22), -CN and -O-R20; and wherein said C1-6 alkyl, aralkyl, cycloalkyl, aryl, heterocyclyl or heteroaryl are further optionally substituted with one, two or three substituents independently selected from the group consisting of hydroxyl, halo, -NO2, -N (R20) ( R22), -C (O) -R20, -C (O) -OR20, -C (O) -N (R20) (R22), -CN and -O-R20; or R2 and R4 may join together with the atom to which they are attached to form a heterocyclyl or heteroaryl; wherein said heterocyclyl or heteroaryl are optionally substituted with one, two or three substituents independently selected from the group consisting of halo, C1-6, cycloalkyl, heteroaryl, -CN, -O-R20, -N alkyl (R20) (R22 ), -C (O) -R20, -N (R20) -C (O) -OR20, and -C (O) -OR20; and wherein said C1-6 alkyl or heteroaryl are optionally substituted with one, two or three substituents independently selected from the group consisting of halo, -CN, -O-R20, C1-6 alkyl, aryl and heteroaryl; R5 is hydrogen, C1-6 alkyl, cycloalkyl, aryl, heteroaryl or heterocyclyl; wherein said C1-6 alkyl, cycloalkyl, aryl, heteroaryl or heterocyclyl are optionally substituted with one, two or three substituents independently selected from the group consisting of halo, -NO2, cycloalkyl, aryl, heterocyclyl, heteroaryl, -N (R20 ) (R22), -C (O) -R20, -C (O) -OR20, -C (O) -N (R20) (R22), -CN and -O-R20; wherein said cycloalkyl, aryl, heterocyclyl or heteroaryl are further optionally substituted with one, two or three substituents independently selected from the group consisting of halo, -NO2, C1-6 alkyl, aralkyl, cycloalkyl, aryl, heterocyclyl, heteroaryl alkyl, - N (R20) (R22), -C (O) -R20, -C (O) -OR20, -C (O) - N (R20) (R22), -CN and -O-R20; and wherein said C1-6 alkyl, aralkyl, cycloalkyl, aryl, heterocyclyl or heteroaryl are further optionally substituted with one, two or three substituents independently selected from the group consisting of hydroxyl, halo, -NO2, -N (R20) ( R22), -C (O) -R20, -C (O) -OR20; R6 is C1-6 alkyl, cycloalkyl, aryl, heteroaryl or heterocyclyl; wherein said C1-6 alkyl, cycloalkyl, aryl, heteroaryl or heterocyclyl are optionally substituted with one, two or three substituents independently selected from the group consisting of halo, -NO2, C1-6 alkyl, cycloalkyl, aryl, heterocyclyl, heteroaryl , -N (R20) (R22), -C (O) -R20, -C (O) -OR20, -C (O) -N (R20) (R22), - CN and -O-R20; wherein said C1-6 alkyl, cycloalkyl, aryl, heterocyclyl or heteroaryl are further optionally substituted with one, two or three substituents independently selected from the group consisting of halo, -NO2, C1-6 alkyl, aralkyl, cycloalkyl, aryl, heterocyclyl, heteroaryl, -N (R20) (R22), -C (O) -R20, -C (O) -OR20, -C (O) -N (R20) (R22), -CN and -O-R20 ; and wherein said C1-6 alkyl, aralkyl, cycloalkyl, aryl, heterocyclyl or heteroaryl are further optionally substituted with one, two or three substituents independently selected from the group consisting of hydroxyl, halo, -NO2, -N (R20) ( R22), -C (O) -R20, -C (O) -OR20; or R5 and R6 can be joined together with the atom to which they are attached to form a heterocyclyl or heteroaryl; wherein said heterocyclyl or heteroaryl are optionally substituted with one, two or three substituents independently selected from the group consisting of halo, C1-6, cycloalkyl, heterocyclyl, aryl, heteroaryl, oxo, -CN, -OR20 alkyl, -N ( R20) (R22), -N (R20) -C (O) -R20, -N (R20) -C (O) -OR20, and -C (O) -OR20; and wherein said C1-6 alkyl or heterocyclyl are optionally substituted with one, two or three substituents independently selected from the group consisting of halo, oxo, heteroaryl, and -O-R20; R20 and R22 are selected each independently from the group consisting of hydrogen, C1- 6 cycloalkyl, heterocyclyl, aryl and heteroaryl alkyl; and wherein the C1-6alkyl, cycloalkyl, heterocyclyl, aryl and heteroaryl are optionally substituted with one, two or three substituents independently selected from the group consisting of hydroxyl, halo, C1-4 alkyl, acylamino, oxo, -NO2, -SO2R26, -CN, C1-3 alkoxy, aryloxy, -CF3, -OCF3, -OCH2CF3, -C (O) -NH2, aryl, cycloalkyl and heteroaryl; wherein said heteroaryl is further optionally substituted with C1-4 alkyl or cycloalkyl; or when R20 and R22 are attached to a common nitrogen atom R20 and R22 may join to form a heterocyclyl or heteroaryl which are then optionally substituted with one, two or three substituents independently selected from the group consisting of hydroxyl, halo, C1-4, aralkyl, aryloxy, aralkyloxy, acylamino, -NO 2, -SO2R26, -CN, C1-3 alkoxy, -CF3, -OCF3, aryl, heteroaryl and cycloalkyl; and each R26 is independently selected from the group consisting of hydrogen, C1-4alkyl, aryl and cycloalkyl;