Synthesis of OSW-1 analogues and a dimer and their antitumor activities

Xingquan Ma,Biao Yu,Yongzheng Hui,Ze-Hong Miao,Jian Ding

Synthesis of OSW-1 analogues and a dimer and their antitumor activities

2001

Xingquan Ma
Biao Yu
Yongzheng Hui
Ze-Hong Miao
Jian Ding

Five analogues, including a 16-epi-isomer (6), and a 3-terephthalic acid linked dimer (8) of OSW-1 were synthesized. Their inhibitory activities on P388 and A-549 cells were detected.

Keywords:

Aglycone
Dimer
Biochemistry
Ketone
Epimer
Organic chemistry
Glycoside
Saponin
Steroid
Chemistry
Cytotoxicity
Disaccharide
Chemical synthesis
Stereochemistry

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