Catalyst-Free, One-Pot, Three-Component Synthesis of Pyrimido[4,5-b] Quinoline-4-Amines under Microwave Irradiation
2018
An efficient and facile one-pot, three-component protocol for the synthesis of pyrimido[4,5-b]quinoline-4-amines from the condensation of 2-aminoquinoline-3-carbonitrile, N,N-dimethylformamide dimethyl acetal and primary amines under microwave irradiation is reported. This efficient, straightforward procedure led to the desired products in high yields without the need for a catalyst or for a tandem addition–elimination–cyclisation reaction.
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