High fidelity biopotential recordings in mice using a novel telemetry implant

We have developed a fully implantable telemetry device for use in mice. The telemeter is able to measure biopotential signals (EEG, EMG, ECG) at a sampling rate of 2000 Hz. The device has a volume of 1.45 cc with a unique contour design for subcutaneous implantation in mice over 20 gm in weight. A novel aspect to the device is that it contains no battery. Power to run the telemeter is provided by a wireless power pad placed under the cage of the animal. This provides continual operation of the telemeter (>90% data collection in a 24 hour period) during a range of normal animal behaviours. We have assessed the ability of this device to record biopotential signals for up to 3 months. We believe this technology offers new experimental paradigms to be explored.