Alternanthera sessilis leaf fractions possess in vitro inhibitory activities in mammalian α-amylase and α-glucosidase

Acute respiratory distress syndrome (ARDS) is a most common complication in patients with severe COVID-19 with high rate of mortality Corticosteroids have been used in the management of SARS-CoV and MERS-CoV several years ago Data about the effectiveness of corticosteroids in the management of COVID-19 is lacking It has been proposed that the corticosteroids have a modulatory effect by suppressing cytokine storms in severe COVID-19 The aimed of this study is to review literature that discussed the use of corticosteroids in patients with COVID-19 related ARDS Pubmed database was used to select the article in this review with the keywords SARS-CoV-2, COVID-19, corticosteroid, pneumonia, and ARDS Elderly and patients with underlying disease are more likely to develop severe COVID-19 and lead to ARDS Because of the immunosuppressive activity, corticosteroid could modulate the cytokine storms in COVID-19 patients with ARDS The use of corticosteroids may offer the benefit in COVID-19 with ARDS, by reduce the mortality rate and duration of treatment The administration of corticosteroids should be considered in COVID-19 patients with signs of ARDS and refractory shock The low until moderate dose and short treatment of corticosteroids are recommended to minimize the adverse effects [ABSTRACT FROM AUTHOR] Copyright of Pharmaceutical Sciences Asia is the property of Mahidol University, Faculty of Pharmacy and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission However, users may print, download, or email articles for individual use This abstract may be abridged No warranty is given about the accuracy of the copy Users should refer to the original published version of the material for the full abstract (Copyright applies to all Abstracts )