A Potential Role for Nerve Growth Factor in Regulating the Maturation of Inhibitory Neurotransmission

Interneurons mediate inhibition in the CNS by releasing GABA, which hyperpolarizes postsynaptic neurons by promoting chloride entry through GABAA receptors. Low levels of intracellular chloride ([Cl−]i) in postsynaptic neurons, maintained by the chloride exporter KCC2, are required for the