Rabeprazole sodium tablet and rabeprazole sodium enteric-coated tablet

2015 
The invention provides a rabeprazole sodium tablet which comprises the following components in part by weight: 20-40 parts of rabeprazole sodium, 260-300 parts of lactose, 50-80 parts of magnesium silicate, 35-45 parts of magnesium oxide and 1-5 parts of microcrystalline cellulose. According to the invention, the components of the rabeprazole sodium tablet and the dosage of each component are controlled, and the rabeprazole sodium tablet has high dissolution rate and bioavailability through the integrated action of all components and is reasonable in component design. Experimental results show that the dissolution rate of the rabeprazole sodium tablet is 97.5%. The invention further provides a rabeprazole sodium enteric-coated tablet which is prepared from the rabeprazole sodium tablet above; the rabeprazole sodium tablet is reasonable in component design, so that the prepared rabeprazole sodium enteric-coated tablet has good stability.
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