Platinum-Based Anticancer Agents
2021
A platinum-based anticancer drug is any agent that contains one or more platinum atoms in the oxidation state of II or IV, contains mono- or multidentate non-labile am(m)ine carrier ligands and labile chlorido or bidentate carboxylate ligands, and which acts as a prodrug; it undergoes aquation to yield a reactive complex capable of forming coordinate bonds with DNA bases. Its binding to DNA prevents replication and transcription which causes cell death through apoptosis.
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