A Facile and General Synthesisof 2β-Aminosteroids
2009
A facile and general synthesis of 2β-aminosteroids in high yields from 2,3a-epoxy-5a-androstan-17-one by regioselective aminolysis is developed using a zinc chloride/water catalytic system. The reaction is successful with both aliphatic and aromatic amines as well as with azoles.
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