Influence of pyrazine derivatives on the day of vaginal opening in juvenile female rats

Effects of pyrazine derivatives on the day of the first opening of the vagina in juvenile female rats were studied. Tetraethyl and 2, 5-dimethyl pyrazine caused a significant delay in the first vaginal opening day of juvenile female rats, but no delay was noted in the case of 2, 5-diethyl or triethyl pyrazine. These results suggest that tetraethyl and 2, 5-dimethyl pyrazine cause delays in the onset of puberty in juvenile female rats.