New homobimetallic organotin(IV) dithiocarbamates as potent antileishmanial agents

In the present study, di- and triorganotin(IV) dithiocarbamates, (n-Bu2SnCl)2L (1), (Ph2SnCl)2L (2), (Ph3Sn)2L (3), and (Bz3Sn)2L (4), have been synthesized, where L is 4,4-trimethylenedipiperidine-1-carbodithioate. The coordination mode of the ligand to Sn, structural confirmation and geometry assignment around Sn(IV), in solid and solution forms, were made using FT-IR, multinuclear NMR (1H and 13C), and X-ray single crystal analysis. The latter technique confirms anisobidentate mode of chelation of the ligand with Sn, in 1–4, with distorted trigonal bipyramidal or square pyramidal geometry. Complexes 1–4 present supramolecular structures mediated by different C⋯H and Cl⋯H intermolecular interactions. These complexes maintain five-coordination even in solution, except for 4. The antileishmanial activity of all complexes are well above the standard drug, especially (Bz3Sn)2L. The Docking studies suggest that high antileishmanial action of (Bz3Sn)2L is due to its lowest binding energy with enzyme trypanoth...