Enzymatic In Vitro Reduction of Ketones. Part 111. The Unexpected Steric Course of the HLAD Catalyzed Reduction of 3-Cyanocyclohexanone
2010
3-Cyanocyclohexanone is a suitable substrate for preparative HLAD reduction, delivering enantiomerically pure (1S, 3S)-trans and (1R, 3S)-cis-alcohols. Details are given on the kinetics of the reduction and the absolute configuration of the products.
In contrast to recently developed reaction models an important amount of (1R,3S)-cis-alcohol is formed.
Some side reactions of the substrate with the TRIS-buffered medium are described.
Keywords:
- Correction
- Source
- Cite
- Save
- Machine Reading By IdeaReader
24
References
8
Citations
NaN
KQI