Clinical, pharmacokinetic and pharmacodynamic evaluations of metronomic UFT and cyclophosphamide plus celecoxib in patients with advanced refractory gastrointestinal cancers

Giacomo Allegrini,Teresa Di Desidero,M. T. Barletta,Anna Fioravanti,Paola Orlandi,Bastianina Canu,Silvio Chericoni,Fotios Loupakis,Antonello Di Paolo,Gianluca Masi,Andrea Fontana,Sara Lucchesi,G Arrighi,Mario Giusiani,A. Ciarlo,Giovanni Brandi,Romano Danesi,Robert S. Kerbel,Alfredo Falcone,Guido Bocci

Clinical, pharmacokinetic and pharmacodynamic evaluations of metronomic UFT and cyclophosphamide plus celecoxib in patients with advanced refractory gastrointestinal cancers

2012

Aims To evaluate UFT and cyclophosphamide (CTX) based metronomic chemotherapy plus celecoxib (CXB) for the treatment of patients with heavily pre-treated advanced gastrointestinal malignancies.

Keywords:

Refractory
Celecoxib
Pharmacodynamics
Tegafur
Oncology
Cyclophosphamide
Biology
Internal medicine
Metronomic Chemotherapy
Pharmacokinetics
in patient

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