Pirt reduces bladder overactivity by inhibiting purinergic receptor P2X3
2015
The cause of overactive bladder is largely unknown and there is currently no effective therapy. Gao et al. show that a membrane protein Pirt controls bladder emptying by inhibiting the neuronal purinergic receptor P2X3 and that treatment with a small Pirt fragment prevents bladder overactivity in mice.
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