LIN28 phosphorylation by MAPK/ERK couples signalling to the post-transcriptional control of pluripotency

Kaloyan M. Tsanov,Daniel S. Pearson,Zhaoting Wu,Areum Han,Robinson Triboulet,Marc T. Seligson,John T. Powers,Jihan K. Osborne,Susan Kane,Steven P. Gygi,Richard I. Gregory,George Q. Daley

LIN28 phosphorylation by MAPK/ERK couples signalling to the post-transcriptional control of pluripotency

2017

Kaloyan M. Tsanov
Daniel S. Pearson
Zhaoting Wu
Areum Han
Robinson Triboulet
Marc T. Seligson
John T. Powers
Jihan K. Osborne
Susan Kane
Steven P. Gygi
Richard I. Gregory
George Q. Daley

Daley and colleagues report that MAPK signalling controls pluripotency in embryonic stem cells and during somatic cell reprogramming by enhancing the stability and effects of LIN28 on direct mRNA targets through its phosphorylation by ERK.

Keywords:

LIN28
Molecular biology
Cell biology
MAPK/ERK pathway
Reprogramming
Phosphorylation
Somatic cell
Rex1
Embryonic stem cell
Biology
Post-transcriptional regulation

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