In Vitro Anti-HIV Effect of Voacamine from Voacanga africana Stapf Based on the SPRi Experiment

AIDS/HIV is a serious life-threatening and public health problem that urges for new antiviral drugs to control. A bis-indole alkaloid voacamine has been isolated from Voacanga africana Stapf. In this study, voacamine 1H and 13C chemical shift assignments were redetermined using 1D and 2D NMR; 1H NMR and 13C NMR chemical shifts were accurately assigned. Absolute configuration was confirmed by single-crystal X-ray diffraction analysis with Cu Kα radiation, and in vitro antiviral activity against HIV via effecting the binding affinity with gp120 based on SPRi experiment was testified. This study supports the potential value of voacamine as a natural agent against AIDS/HIV.