Efficacy of photothermal ablation using intravenously delivered NIR-absorbing nanorods in colon cancer
2009
The use of near-infrared absorbing nanoparticles recently has been proposed for the minimally invasive photothermal
ablation of solid tumors, and this approach currently is being investigated in the clinic. One class of nanoparticles, gold
nanorods, has been investigated for the ablation of various cancer types using both direct injection and systemic delivery.
Here we investigate the photothermal ablation of colon cancer in an animal model using intravenously delivered gold
nanorods. Nanorods with an aspect ratio of ~3.2 and an extinction peak of 774 nm were PEGylated, suspended in an
isotonic solution, and infused into the tail vein of BALB/c mice bearing subcutaneous CT26.wt murine colon cancer
tumors. After 24 hrs, an isotropic laser fiber was inserted through a small incision in the skin to a point proximate to and
beneath the tumor. The area was illuminated with 3.5 W average power for 3 minutes. Control groups consisted of
laser-only, nanorod-only and untreated tumored animals. The survival of the animals receiving nanorod-based
photothermal ablation was statistically longer than the control groups with >44% complete response. This work
demonstrates the promise of systemically delivering nanoparticles to tumors for thermal ablation
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