Kinetics of fumonisin B 1 in pigs and persistence in tissues after ingestion of a diet containing a high fumonisin concentration

The absorption, distribution and elimination of fumonisin B 1 (FB 1 ) and its metabolites was investigated in pigs. For the determination of the absorption and biotransformation of FB 1 , T-cannula were implanted into the distal part of experimental pigs’ ileum and the total urine and faeces moiety was collected during the toxin feeding (45 mg FB 1 /kg diet, duration: 10 days) and in the subsequent elimination period (10 days). At the end of trial several organs, muscle and fat samples were also collected. The accumulative absorption of fumonisin B 1 was 4%. In the chymus, the FB 1 conversion to aminopentol (totally hydrolysed FB 1 ; AP 1 ) and partially hydrolysed FB 1 (PHFB 1 ) was 1% and 3.9%, respectively. Derivatives of FB 1 were mostly accumulated in the liver and kidney, while in negligible concentration could be detected in the muscle and fat samples. In the organs the efficacy of the FB 1 to AP 1 and PHFB 1 conversion was 30% and 20%, respectively. In the faecal content the main hydrolised produc...