Bile acid receptor agonist GW4064 regulates PPARγ coactivator-1α expression through estrogen receptor-related receptor α

Shailendra Kumar Dhar Dwivedi,Nidhi Singh,Rashmi Kumari,Jay Sharan Mishra,Sarita Tripathi,Priyam Banerjee,Priyanka Shah,Vandana Kukshal,Abdul Malik Tyagi,Anil N. Gaikwad,Rajnish Kumar Chaturvedi,Durga Prasad Mishra,Arun Kumar Trivedi,Somali Sanyal,Naibedya Chattopadhyay,Ravishankar Ramachandran,Mohammad Imran Siddiqi,Arun Bandyopadhyay,Ashish Arora,Thomas Lundåsen,Sayeepriyadarshini Anakk,David D. Moore,Sabyasachi Sanyal

Bile acid receptor agonist GW4064 regulates PPARγ coactivator-1α expression through estrogen receptor-related receptor α

2011

Synthetic FXR agonist GW4064 activates ERR proteins and through ERRα regulates PGC-1α expression. Further, FXR physically interacts with ERR and protects it from SHP repression.

Keywords:

Psychological repression
Biology
Biochemistry
Estrogen receptor
Agonist
Estrogen
Coactivator
Mitochondrion
Cell culture
Receptor
Endocrinology
Internal medicine

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